The transcriptomic response to irinotecan in colon carcinoma bearing mice preconditioned by fasting

Gold nanoparticle-induced sonosensitization enhances the antitumor activity of ultrasound in colon tumor-bearing mice

Introduction: Light-driven cancer therapy strategies (e.g. photodynamic therapy and photothermal therapy) have undergone remarkable progress in recent years, but they still suffer from a serious drawback of limited penetration depth of light in tissue. As a non-invasive and non- ionizing radiation, ultrasound can be focused remotely, transferring acoustic energy deep in the bo...

antitumor efficacy of rgd-targeted liposomes containing doxorubicin in mice bearing c-26 colon carcinoma

Failure to inhibit the formation of mammary carcinoma in mice by intermittent fasting.

Chronic restriction of caloric intake inhibits the formation of various types of tumors in the mouse. This inhibition is evidenced both by a decrease in the proportion of mice developing tumors and by a delay in the time at which the tumors appear (4-6, 8, 11, 15, 16). The magnitude of the inhibi tory effect is dependent on the degree of caloric re striction (1, 10, 14), the type of tumor (11),...

Pharmacokinetics and therapeutics of sterically stabilized liposomes in mice bearing C-26 colon carcinoma.

Three different liposome types were compared for blood clearance and tissue uptake in mice bearing C-26 colon carcinoma growing either s.c. or in liver. Therapeutic experiments were performed with the liposome preparation showing the highest tumor uptake. Liposomes were composed of solid-phase phosphatidylcholine, either distearoyl phosphatidylcholine or hydrogenated soy phosphatidylcholine, an...

Microscopic localization of sterically stabilized liposomes in colon carcinoma-bearing mice.

Using light and electron microscopy, we investigated the in vivo distribution of liposomes sterically stabilized by specific lipids which prolong their circulation in blood. Tissue distribution of sterically stabilized liposomes composed of distearoyl phosphatidylcholine:cholesterol:monosialoganglioside GM1 (10:5:1)-encapsulated 67Ga-Desferal indicates that more than 30% of liposomes still rema...